Red Rice DE 40 Alleviates High-fat Diet-induced Hyperlipemia by Lowering Lipid Profiles in Rats

Background: Hyperlipidaemia is characterised by an abnormal increase in one or more lipids in plasma, and is a major contributor to obesity, coronary heart disease, myocardial infarction, and stroke if they are not treated promptly. Objectives: In this study, we intended to discover the therapeutic actions of Red Rice DE 40 (RR DE 40) on high-fat diet (HFD)-induced rats. Materials and Methods: The experimental rats were fed with HFD for 90 days to initiate the hyperlipidaemia and subsequently treated with 250 and 500 mg/kg of RR DE 40 from 60th to 90 days. The body weight of the rats was measured regularly. After the scarification, the blood, liver, and adipose tissue specimens were collected for biochemical assays. The liver and adipose tissues were weighed properly. The levels of haematological indices were counted using a haemocytometer. The levels of biochemical markers and liver marker enzymes were assessed using standard methods. The levels of lipid profiles were determined by standard methods. The excised liver and adipose tissues were analysed microscopically by histopathological analysis. Results: RR DE 40 treatment effectively decreased the body weight gain in the HFD-induced rats. The liver and adipose tissue weight was also reduced by the RR DE 40 treatment. The changes in the haematological parameters such as RBC, WBC, Hb, monocytes, lymphocytes, and polymorphs were modulated by the RR DE 40 treatment on EG-induced rats. The levels of total protein, albumin, glucose, and urea and activities of SGOT and SGPT were substantially decreased by the RR DE 40 treatment. The RR DE 40 treatment also diminished the status of TC, TG, LDL, and VLDL in the HFD-treated rats. The findings of histopathological analysis also witnessed the therapeutic effects of RR DE 40. Conclusion: The findings of this work highlighted that RR DE 40 is effective in HFD-induced hyperlipidaemia, probably due to its lipid-lowering potential. Hence, it may be used for the treatment of hyperlipidaemia-associated diseases.