Open access · Peer reviewed · Scopus journal
Comparison of the postoperative analgesia of intravenous infusion of adenosine and fentanyl
- 1*,
- 2,
- 3,
- 4,
- 5
- 1Department of Oral and Maxillofacial surgery, BVU Dental College, Sangli, Maharashtra, India.
- 2SB Patil Dental College, Bidar, Karnataka, India.
- 3Pananeeya Table 1: Summed pain relief and pain intensity scores Drugs Mean TOPAR (±SD) Mean SPID (±SD) 8 h 24 h 8 h Aceclofenac 24.5 (±3) 72.7 (±8.54) 15.1 (±4.18) Diclofenac sodium 17.8 (±3) 58.4 (±12.4) 10.0 (±3.55) TOPAR=Total pain relief over; SPID=Summed PID over Table 2: Adverse events profile of study drugs Adverse event Aceclofenac Diclofenac sodium (n=25) (n=25) Nausea ‑ 2 Gastritis 1 3 Epigastric pain 1 4 Fluctuance 1 2 Indigestion 1 3 Hypersensitivity reactions 1 1 Dizziness 2 4 Total 7 19 Dental College, Hyderabad, India.
- 4Oral and Maxillofacial surgery, Kalinga Institute of Dental sciences, Bhubneswar, Odisha, India.
- 5Periodontics, GITAM Dental College, Vishakapatnam, Andhra Pradesh, India.
Published in Journal of Pharmacology and Pharmacotherapeutics
Correspondence: Nagendra S. Chunduri
Department of Oral and Maxillofacial surgery, BVU Dental College, Sangli, Maharashtra, India.
Email: srinivasomfs@gmail.com
Copyright: © 2013 The Author(s). This is an open access article.
Abstract
Significantly higher pain and FLACC behavior scale score were observed with fentanyl at 2 hours as compared to adenosine 15‑50 µg/kg/min [Table 1]. Fentanyl and adenosine 15‑50 µg/ kg/min had shown significantly less FLACC behavior scale scores at 8 hours as compared to adenosine 4‑6 µg/kg/min [Table 1]. Patients with adenosine 15‑50 µg/kg/min were more or less comfortable during the first 8 hours of study, whereas fentanyl group patients were more comfortable after 12 hours as observed with FLACC scale. Fukunaga et al. (2003) also observed significantly reduced pain scores in their study with adenosine.
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