Synergistic depressant activity of Amorphophallus paeoniifolius in Swiss albino mice

Pharmacodynamic synergism results from two drugs directed at a similar receptor target or physiological system. Synergistic activity of tea samples with antibiotics showed best response against the bacteria. The synergistic effect from the association of antibiotic with plant extracts against resistant bacteria enables the use of the respective antibiotic when it is no longer effective by itself during therapeutic treatment. Generally neurotransmitters are involved in the work of regulation of central nervous system (CNS) activity. GABAA receptors are located postsynaptically and they mediate postsynaptic inhibition by increasing the Cl- permeability and hyperpolarizing the cell. GABAA receptors are target for the several important centrally acting drugs like benzodiazepines, barbiturates, etc. Similarly the tuber of the Ayurvedic plant A. paeoniifolius were found to have CNS depressant activity in mice. So the present study was planned to find out the interaction of the extracts with the benzodiazepines and barbiturates receptor agonist.